Fig. 2

STING activated signalling pathways. STING activation leads to translocation from ER membranes to the perinuclear vesicles where it induces the signalling of two major pathways: the NF-κB -dependent proinflammatory response and the IRF3-dependent type I interferon response. The activation of mitochondrial antiviral adaptor MAVS also results in the activation of STING and recruitment of TBK1, which upregulates the transcription of antiviral chemokines via STAT6