Regulating STING in health and disease

Table 4 Summary of interferon-stimulated genes (ISGs)

Apoptosis	Immune Modultion	Cell Attraction & Adhesion	Antiviral & Pathogen Detection
CASP4 CASP8 BAK1 Fas/ CD95 PLSCR1 XAF-1 DAP kinase RID	MxA MxB ICAM1 SELL CD47 ALCAM IRF1–5 & 7 LGALS3B IFN-γ IL-12 TNF-α SOCS USP18	VEGF FGF VRP PDGFRL ECGF1 EREG CTGF MHC I&II	OAS1 Protein Kinase R Viperin Tetherin IFI6 IFITM2 IFITM3 IRF1 IRF7 MHC I&II Ribonuclease L GTPase Mx1 ISG15 ISG20 ADAR1 APOBEC

Expression of ISGs are induced by type I interferon via the JAK-STAT signalling pathway. ISGs are involved in a wide spectrum of cellular activities including apoptosis, immune modulation, cell migration and adhesion, and antiviral responses. Some ISGs have multiple roles in immune regulation but are not repeatedly indicated in the table

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