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|
Group
|
Sham
|
CLP
|
CLP + LDK378
|
|---|
|
MAP (mmHg)
|
|
BL
|
124 ± 5.70
|
124.8 ± 6.91
|
123.2 ± 4.38
|
|
6 h
|
120 ± 6.78
|
99.6 ± 9.24*
|
98 ± 4.74*
|
|
30 h
|
113.4 ± 11.72
|
69.6 ± 12.93*
|
86.4 ± 5.68*#
|
|
54 h
|
115.2 ± 6.38
|
46 ± 13.08*
|
74.4 ± 7.06*#
|
|
PVD (mm/mm2)
|
|
BL
|
18.91 ± 0.756
|
18.24 ± 0.62
|
18.63 ± 0.51
|
|
6 h
|
18.9 ± 0.56
|
16.44 ± 2.61*
|
16.87 ± 1.14
|
|
30 h
|
18.45 ± 0.45
|
13.56 ± 2.19*
|
16.14 ± 1.33*#
|
|
54 h
|
18.63 ± 0.86
|
12.45 ± 2.41*
|
15.49 ± 1.01*#
|
|
MFI
|
|
BL
|
2.9 ± 0.14
|
2.9 ± 0.14
|
2.95 ± 0.11
|
|
6 h
|
2.85 ± 0.14
|
2.55 ± 0.27
|
2.6 ± 0.45
|
|
30 h
|
2.7 ± 0.11
|
1.85 ± 0.22*
|
2.3 ± 0.33*#
|
|
54 h
|
2.55 ± 0.21
|
1.5 ± 0.18*
|
2.05 ± 0.33*#
|
- BL indicates baseline, MAP mean arterial pressure, MFI microcirculatory flow index, PVD perfused vessel density. *p < 0.05 compared with Sham group; #p < 0.05 compared with CLP group
