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Table 2 Distribution of SNP variations among study participants - Additive model

From: SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren’s syndrome

SNP Risk Allele SSa (n = 82) n (%) DESb (n = 98) n (%) P (χ2) CEUc Freq. (HapMap)
TNFα (rs1800629) G Homozygote G 58 (70.8) 83 (84.7) 67.3  
  Heterozygote 22 (26.9) 11 (11.2) 31  
Homozygote A 1 (1.3) 2 (2.1) 1.8  
  0.02   
IL10 (rs1800896) A Homozygote G 13 (15.9) 21 (21.4) 27.4  
  Heterozygote 36 (44.0) 42 (42.9) 51.3  
Homozygote A 32 (39.1) 35 (35.7) 21.2  
  0.64   
TNFAIP3 (rs2230926) G Homozygote T 73 (89.2) 85 (86.7) 94.7  
  Heterozygote 8 (9.8) 10 (10.3) 5.3  
Homozygote G 0 0 0  
  0.54   
  1. a- ss (Sjogren’s Syndrome); b − DES (Dry Eye Syndrome)
  2. c − CEU (C): Utah residents with Northern and Western European ancestry from the CEPH collection. Data is available at Hapmap
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Journal of Inflammation

ISSN: 1476-9255

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