Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest

Table 3 Comparison of intestinal alkaline phosphatase (iAP) mRNA expression in intestinal tissue

Tissue	iAP Relative mRNA Levels by Intervention Group Median (Intra-Quartile Range)					P value (Kruskal-Wallis)	Significant Post-HOC Group Comparisons
Tissue	AC (0)	CPB/DHCA (1)	CPB/DHCA + AP Low (2)	CPB/DHCA + AP Medium (3)	CPB/DHCA + AP High (4)	P value (Kruskal-Wallis)	Significant Post-HOC Group Comparisons
Jejunum	1.00 (0.70–1.99)	1.08 (0.60–2.20)	0.96 (0.79–1.20)	2.00 (1.07–2.85)	0.77 (0.37–1.57)	0.37
Ileum	1.04 (0.82–1.33)	2.85 (1.14–5.71)	3.06 (2.21–5.14)	2.64 (1.93–6.14)	4.38 (2.15–10.35)	0.027	0 vs. 2; 0 vs. 3; 0 vs. 4
Colon	1.00 (0.22–1.18)	1.99 (0.20–8.76)	1.72 (0.87–2.09)	1.02 (0.24–4.55)	1.98 (1.41–3.25)	0.49

Group 0 = Anesthesia controls (AC); Group 1 = Animals undergoing CBP/DHCA; Group 2 = Animals undergoing CPB/DHCA with low dose BiAP (3 U/kg bolus followed by 1 U/kg/hr. infusion); Group 3 = Animals undergoing CPB/DHCA with medium dose BiAP (15 U/kg bolus followed by 5 U/kg/hr. infusion); Group 4 = Animals undergoing CPB/DHCA with high dose BiAP (75 U/kg bolus followed by 25 U/kg/hr. infusion). Data are expressed as medians with intra-quartile ranges. Kruskal-Wallis test was performed followed by post-hoc non-parametric Mann-Whitney U-test as appropriate. Bold: significant at p < 0.05

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