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  1. Inflammatory molecular signals are modulated by a variety of intracellular transduction pathways, the activation of which may induce and amplify the spread of inflammatory response. Suppresser of cytokine sign...

    Authors: Na Meng, Ning-Ning Ji, Ziming Zhou, Yicheng Qian, Yu Tang, Kangbo Yang, Binbin Chen and Yong-Mei Zhang

    Citation: Journal of Inflammation 2020 17:12

    Content type: Research

    Published on:

  2. Prediction and identification of cytotoxic T lymphocyte (CTL) epitopes from tumor associated antigens is a crucial step for the development of tumor immunotherapy strategy. Endocan has been identified as antig...

    Authors: Gaohai Shao, Qingjun Liu, Ling Yang, Guibo Feng, Wang Zhao, Zhongyan Huang and Zhao Yang

    Citation: Journal of Inflammation 2020 17:10

    Content type: Research

    Published on:

  3. The antisense cerebellar degenerative-related protein-1 (CDR1as) has been identified as a sponge for several microRNAs. MiR-641 has been shown to be downregulated in osteoarthritic human chondrocytes, but its ...

    Authors: Wei Zhang, Chi Zhang, Chengfang Hu, Congfeng Luo, Biao Zhong and Xiaowei Yu

    Citation: Journal of Inflammation 2020 17:8

    Content type: Research

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  4. Therapeutic potential of low-intensity ultrasound (LIUS) has become evident in various musculoskeletal diseases. We have previously shown that LIUS has an inhibitory effect on local edema in various diseases i...

    Authors: Kil Hwan Kim, Hyeon-Woo Im, Mrigendra Bir Karmacharya, Sejong Kim, Byoung-Hyun Min, So Ra Park and Byung Hyune Choi

    Citation: Journal of Inflammation 2020 17:7

    Content type: Research

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  5. The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination i...

    Authors: Mehdi Hassanpour, Fateme Hajihassani, Amirataollah Hiradfar, Nasser Aghamohammadzadeh, Reza Rahbarghazi, Nasser Safaie, Mohammad Nouri and Yunes Panahi

    Citation: Journal of Inflammation 2020 17:6

    Content type: Review

    Published on:

  6. There is a complex interplay between inflammatory response and coagulation in sepsis. Heparin is used as a recognized anticoagulant and possesses multiple biological properties that possibly affect sepsis. Thi...

    Authors: Xu Li, Lu Li, Yuequan Shi, Sihan Yu and Xiaochun Ma

    Citation: Journal of Inflammation 2020 17:5

    Content type: Research

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  7. Acupoint application therapy (AAT) has been widely used to treat allergic inflammation induced by allergic rhinitis (AR). The therapeutic effect of acupoint application is obvious. But the underlying therapeut...

    Authors: Wenzhan Tu, Xiaolong Chen, Qiaoyun Wu, Xinwang Ying, Rong He, Xinfa Lou, Guanhu Yang, Kecheng Zhou and Songhe Jiang

    Citation: Journal of Inflammation 2020 17:4

    Content type: Research

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  8. Glioma is an aggressive common cancer with high mortality worldwide. Up to date, the effective medical therapeutical strategy is limited. Numerous previous studies have indicated that glioma-expressed antigen ...

    Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Guibo Feng, Qijiang Xiong, Ling Yang and Zhao Yang

    Citation: Journal of Inflammation 2020 17:3

    Content type: Research

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  9. The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many studies. However, the specific mechanism remains unclear. This study was...

    Authors: Guang-chun Wang, Tian-run Huang, Yang-yang Hu, Ke-yi Wang, Heng Shi, Lei Yin and Bo Peng

    Citation: Journal of Inflammation 2020 17:2

    Content type: Research

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  12. Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet’s disease (BD). This study aimed to perform a meta-analysis of eligible studies ...

    Authors: Elham Shahriyari, Leila Vahedi, Nasrin Roshanipour, Mohammad Asghari Jafarabadi, Amin Khamaneh and Maryam Ghaffari Laleh

    Citation: Journal of Inflammation 2019 16:26

    Content type: Research

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  13. Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors.

    Authors: Miguel Hueso, Angela Casas, Adrian Mallén, Laura de Ramón, Nuria Bolaños, Cristian Varela, Josep M. Cruzado, Joan Torras and Estanislao Navarro

    Citation: Journal of Inflammation 2019 16:25

    Content type: Research

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  14. Neuregulin receptor degradation protein-1 (Nrdp1) is an E3 ubiquitin ligase that plays an important role in regulating cell growth, apoptosis and oxidative stress. However, the data regarding its expression an...

    Authors: Changlong Zhou, Qingjun Liu, Wang Zhao, Ling Yang, Zhongyan Huang and Zhao Yang

    Citation: Journal of Inflammation 2019 16:24

    Content type: Research

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  16. Lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus patients. Mesangial cells (MCs) comprise a third of the glomerular cells and are key contributors to fibrotic changes withi...

    Authors: Rachael D. Wright, Paraskevi Dimou, Sarah J. Northey and Michael W. Beresford

    Citation: Journal of Inflammation 2019 16:22

    Content type: Research

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  17. Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their f...

    Authors: Li Wang, Linjie Feng and Jingyu Zhang

    Citation: Journal of Inflammation 2019 16:21

    Content type: Commentary

    Published on:

    The original article was published in Journal of Inflammation 2019 16:13

  18. There is growing recognition of the association of CP/CPPS accompany with ED. However, the specific mechanism of action remains unclear. The aim of this study was to investigate structural and functional abnor...

    Authors: Tianrun Huang, Guangchun Wang, Yangyang Hu, Heng Shi, Keyi Wang, Lei Yin and Bo Peng

    Citation: Journal of Inflammation 2019 16:20

    Content type: Research

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  19. Emerging evidence has demonstrated that inflammation is involved in the occurrence and development of diabetic neuropathic pain (DNP). The anti-inflammatory property of interleukin (IL)-35 makes it a promising...

    Authors: Yinghai Jiang, Jing Wang, Haiqin Li and Lingjie Xia

    Citation: Journal of Inflammation 2019 16:19

    Content type: Research

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  20. Caused by Mycobacterium tuberculosis, tuberculosis (TB) is an extremely contagious disease predominantly affecting the lungs. TB is found worldwide and has a major impact on public health safety primarily due to ...

    Authors: Paulo R. Z. Antas, Carlos G. G. Ponte, Matheus R. Almeida, Lawrence H. P. Albuquerque, Periela S. Sousa-Vasconcelos, Thaíze Pedro, Natália L. S. Gomes, Otacílio C. Moreira, Fernanda C. Silva, Luíz R. R. Castello-Branco and Rosa T. Pinho

    Citation: Journal of Inflammation 2019 16:18

    Content type: Research

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  21. Obesity-induced skeletal muscle inflammation is a major contributor of skeletal muscle loss/atrophy and is implicated in metabolic complications such as insulin resistance. Fibroblast growth factor 21 (FGF21) ...

    Authors: Chu-Sook Kim, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Jeong Woo Park, Hun Taeg Chung, Eun Roh, Min-Seon Kim, Tae Youl Ha and Rina Yu

    Citation: Journal of Inflammation 2019 16:17

    Content type: Research

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  22. Dysregulated inflammatory response is common cause of organ damage in critical care patients. Preconditioning/tolerance is a strategy to prevent exacerbated inflammation. The aim of this study is to analyze hy...

    Authors: Rosangela Nascimento Pimentel, Ricardo Costa Petroni, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Mariana Macedo Andrade, Suely Kumini Ariga and Francisco Garcia Soriano

    Citation: Journal of Inflammation 2019 16:16

    Content type: Research

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  23. The discovery of the NET network (neutrophil extracellular trap) has revolutionized the perception of defense mechanisms used by neutrophils in infections and non-infectious states, as this mechanism proves th...

    Authors: Paulina Niedźwiedzka-Rystwej, Weronika Repka, Beata Tokarz-Deptuła and Wiesław Deptuła

    Citation: Journal of Inflammation 2019 16:15

    Content type: Review

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  24. Obesity is a risk factor for chronic kidney disease (CKD). While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. The aim of this study was t...

    Authors: Thea Laurentius, Ute Raffetseder, Claudia Fellner, Robert Kob, Mahtab Nourbakhsh, Jürgen Floege, Thomas Bertsch, Leo Cornelius Bollheimer and Tammo Ostendorf

    Citation: Journal of Inflammation 2019 16:14

    Content type: Research

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  25. Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be a promising and effective therapeutic strategy for...

    Authors: Qihong Que, Xinghua Guo, Longxin Zhan, Shaodong Chen, Zengli Zhang, Xiaoming Ni, Bin Ye and Shuanglin Wan

    Citation: Journal of Inflammation 2019 16:13

    Content type: Research

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    The Commentary to this article has been published in Journal of Inflammation 2019 16:21

  26. Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem...

    Authors: Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richard W. Moyer…

    Citation: Journal of Inflammation 2019 16:12

    Content type: Short Report

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  27. Radiation-induced lung fibrosis (RILF) is a severe and life-threatening complication of thoracic radiotherapy. Cell death is the key issue in RILF. Ferroptosis is a form programmed cell death implicated in the...

    Authors: Xuan Li, Lijie Duan, Sujuan Yuan, Xibing Zhuang, Tiankui Qiao and Jian He

    Citation: Journal of Inflammation 2019 16:11

    Content type: Research

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  28. There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]). I...

    Authors: Juan Li, Hidetaka Hara, Yi Wang, Charles Esmon, David K. C. Cooper and Hayato Iwase

    Citation: Journal of Inflammation 2019 16:10

    Content type: Review

    Published on:

  29. Correlations among the aqueous flare value (an indicator of inflammation), functional-morphologic parameters, and aqueous humor levels of growth factors/receptors and inflammatory factors/cytokines were invest...

    Authors: Asako Mashima, Hidetaka Noma, Kanako Yasuda, Hiroshi Goto and Masahiko Shimura

    Citation: Journal of Inflammation 2019 16:9

    Content type: Research

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  30. Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the enga...

    Authors: Mehdi Hassanpour, Reza Rahbarghazi, Mohammad Nouri, Nasser Aghamohammadzadeh, Nasser Safaei and Mahdi Ahmadi

    Citation: Journal of Inflammation 2019 16:8

    Content type: Review

    Published on:

  31. Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of...

    Authors: Cheng-Maw Ho, Shu-Li Ho, Yung-Ming Jeng, Yu-Sheng Lai, Ya-Hui Chen, Shao-Chun Lu, Hui-Ling Chen, Po-Yuan Chang, Rey-Heng Hu and Po-Huang Lee

    Citation: Journal of Inflammation 2019 16:7

    Content type: Research

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  32. Cytokines are known to be key players in dry eye syndrome (DES) and Sjogren’s syndrome (SS) pathogenesis. In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine le...

    Authors: Hadas Ben-Eli, Nir Gomel, Doron Jacob Aframian, Rania Abu-Seir, Riki Perlman, Eldad Ben-Chetrit, dror Mevorach, Geffen Kleinstern, Ora Paltiel and Abraham Solomon

    Citation: Journal of Inflammation 2019 16:6

    Content type: Research

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  33. Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ...

    Authors: Urban Alehagen, Jan Alexander, Jan Aaseth and Anders Larsson

    Citation: Journal of Inflammation 2019 16:5

    Content type: Research

    Published on:

  34. Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular protei...

    Authors: Maiko Kadowaki, Hidenori Yamada, Koichi Sato, Hiroko Shigemi, Yukihiro Umeda, Miwa Morikawa, Yuko Waseda, Masaki Anzai, Yosuke Kamide, Haruka Aoki-Saito, Takeshi Hisada, Fumikazu Okajima and Tamotsu Ishizuka

    Citation: Journal of Inflammation 2019 16:4

    Content type: Research

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  35. Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circ...

    Authors: Weiwei Ge, Qiaohua Hu, Xiangshao Fang, Juanhua Liu, Jing Xu, Juntao Hu, Xuefen Liu, Qin Ling, Yue Wang, He Li, Ming Gao, Longyuan Jiang, Zhengfei Yang and Wanchun Tang

    Citation: Journal of Inflammation 2019 16:3

    Content type: Research

    Published on:

  36. In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification...

    Authors: Sandra Pérez-Baos, Paula Gratal, Juan I. Barrasa, Ana Lamuedra, Olga Sánchez-Pernaute, Gabriel Herrero-Beaumont and Raquel Largo

    Citation: Journal of Inflammation 2019 16:2

    Content type: Research

    Published on:

  37. Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region o...

    Authors: Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T. Hansel, Gaetano Caramori and Carlo Alberto Volta

    Citation: Journal of Inflammation 2019 16:1

    Content type: Review

    Published on:

  39. Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. ...

    Authors: Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang and Jun Mao

    Citation: Journal of Inflammation 2018 15:27

    Content type: Research

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  40. Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF ...

    Authors: Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto and Masahiko Shimura

    Citation: Journal of Inflammation 2018 15:26

    Content type: Research

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  41. The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by r...

    Authors: Yu Du, Peng Ren, Qi Wang, Shu-Kun Jiang, Miao Zhang, Jiao-Yong Li, Lin-Lin Wang and Da-Wei Guan

    Citation: Journal of Inflammation 2018 15:25

    Content type: Research

    Published on:

  42. Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo...

    Authors: Yumiko Syoji, Ryota Kobayashi, Nako Miyamura, Tsukasa Hirohara, Yoshiko Kubota, Nobuo Uotsu, Kei Yui, Yoshihito Shimazu and Mamoru Takeda

    Citation: Journal of Inflammation 2018 15:24

    Content type: Research

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  43. Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer’s d...

    Authors: Nancy H. Mejias, Camila C. Martinez, Marisa E. Stephens and Juan Pablo de Rivero Vaccari

    Citation: Journal of Inflammation 2018 15:23

    Content type: Research

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  45. High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigate...

    Authors: Haoshu Fang, Anding Liu, Xulin Chen, Wenhui Cheng, Olaf Dirsch and Uta Dahmen

    Citation: Journal of Inflammation 2018 15:21

    Content type: Research

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  46. Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 coul...

    Authors: Philipp Stenzel, Kaj Nagorsen, Jonathan Bernd, Ulrike Leppert, Andreas Zakrzewicz and Janine Berkholz

    Citation: Journal of Inflammation 2018 15:20

    Content type: Research

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  47. Degenerative lumbar spondylolisthesis (DLS) is a major cause of spinal canal stenosis and is often related to lower back pain. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokin...

    Authors: Kuo-Yuan Huang, Yu-Hsiang Hsu, Wei-Yu Chen, Hui-Ling Tsai, Jing-Jou Yan, Jung-Der Wang, Wen-Lung Liu and Ruey-Mo Lin

    Citation: Journal of Inflammation 2018 15:19

    Content type: Research

    Published on:

  48. Inflammatory chemokine ligands (CCLs) play an important role in cardiovascular disease and allograft injury. CCLs may independently associate with diminished estimated glomerular filtration rate (eGFR) in stab...

    Authors: Ahmed Zahran, Ahmed Attia, Holly Mansell and Ahmed Shoker

    Citation: Journal of Inflammation 2018 15:18

    Content type: Research

    Published on:

  50. The aim of the study was to investigate the expression of the NEK7-NLRP3 inflammasome signaling pathway in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as...

    Authors: Zhen-Zhen Ma, Hong-Sheng Sun, Ji-Cai Lv, Lei Guo and Qing-Rui Yang

    Citation: Journal of Inflammation 2018 15:16

    Content type: Research

    Published on:

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